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молекула L-arginine
молекула L-arginine

Нобелевские лауреаты 1998 года:

Ф.Ферчготт

Л.Игнарро

Ф.Мурад

аргинин по 1000 мг 90 капсул производства Solgar

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аргинин по 1000 мг 90 капсул производства Solgar

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Библиотека статей об аргинине. Ноябрь 2000. En.

  1. Development of a noninvasive reporter system for gene expression in Porphyromonas gingivalis.
  2. Interaction of two arginine residues in lactate oxidase with the enzyme flavin: conversion of FMN to 8-formyl-FMN.
  3. Glucose-induced [Ca2+]i abnormalities in human pancreatic islets: important role of overstimulation.
  4. Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans.
  5. Endothelin-1 induces an endothelin-A-receptor-dependent and L-NAME-sensitive vasoconstriction in the isolated perfused guinea-pig kidney.
  6. Endothelin/nitric oxide balance influences hepatic ischemia-reperfusion injury.
  7. Augmented expression of tissue endothelin-1 messenger RNA is a common feature in hypertensive rats.
  8. Nitric oxide relaxes the vascular smooth muscle independently of endothelin-1- and U46619-induced intracellular increase of calcium.
  9. Inhibition of nitric oxide synthesis increases erythrocyte membrane fluidity and unsaturated fatty acid content.
  10. Cortisol inhibits cholinergic vasodilation in the human forearm.
  11. Streptokinase binds preferentially to the extended conformation of plasminogen through lysine binding site and catalytic domain interactions.
  12. Evidence for mutations that break communication between the Endo and Topo domains in NaeI endonuclease/topoisomerase.
  13. Artificial nutrition after pancreaticoduodenectomy.
  14. Coimmobilized native macromolecular heparin proteoglycans strongly inhibit platelet-collagen interactions in flowing blood.
  15. Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype.
  16. Betaine-homocysteine methyltransferase (BHMT): genomic sequencing and relevance to hyperhomocysteinemia and vascular disease in humans.
  17. Coinduction of inducible nitric oxide synthase and arginine recycling enzymes in cytokine-stimulated PC12 cells and high output production of nitric oxide.
  18. Testing the 3Q:1R "rule": mutational analysis of the ionic "zero" layer in the yeast exocytic SNARE complex reveals no requirement for arginine.
  19. Pituitary adenylate cyclase-activating polypeptide prevents cytokine-induced cytotoxicity via inhibition of inducible nitric oxide synthase expression in beta TC cells.
  20. Antisense oligodeoxynucleotide effects on the hypothalamic-neurohypophysial system and the hypothalamic-pituitary-adrenal axis.
  21. The murine Otp homeobox gene plays an essential role in the specification of neuronal cell lineages in the developing hypothalamus.
  22. Binding of factor VIIa to tissue factor on human fibroblasts leads to activation of phospholipase C and enhanced PDGF-BB-stimulated chemotaxis.
  23. Role of nitric oxide in adrenocorticotrophin-induced hypertension: L-arginine effects reversed by N-nitro-L-arginine.
  24. Vasopressin V1a receptor antagonism does not reverse adrenocorticotrophin-induced hypertension in the rat.
  25. Involvement of non-neuronal brain cells in AVP-mediated regulation of water space at the cellular, organ, and whole-body level.
  26. Adrenomedullin and myocardial contractility in the rat.
  27. Mechanisms of methyclothiazide-induced inhibition of contractile responses in rat aorta.
  28. Modulation of human chondrocyte metabolism by recombinant human interferon.
  29. Human peptidylarginine deiminase type III: molecular cloning and nucleotide sequence of the cDNA, properties of the recombinant enzyme, and immunohistochemical localization in human skin.
  30. Flow-mediated dilatation.
  31. Nitric oxide mediates a therapeutic effect of nicotine in ulcerative colitis.
  32. Human immunodeficiency virus transactivator protein (Tat) stimulates chemotaxis, calcium mobilization, and activation of human polymorphonuclear leukocytes: implications for Tat-mediated pathogenesis.
  33. Distribution of c-fos mRNA in the brain following intracerebroventricular injection of nitric oxide (NO)-releasing compounds: possible role of NO in central cardiovascular regulation.
  34. Corticotropin-releasing hormone and arginine vasopressin: mRNA and secretion are differentially regulated according to the pattern of exposure to noradrenaline in rat hypothalamic neurones.
  35. Melatonin suppresses lysophosphatidylcholine enhancement of serotonin-induced vasoconstriction in the human umbilical artery.
  36. Melatonin disrupts circadian rhythms of glutamate and GABA in the neostriatum of the aware rat: a microdialysis study.
  37. Inhibition of nitric oxide synthase activity by early and advanced glycation end products in cultured rabbit proximal tubular epithelial cells.
  38. Cyclosporine enhances alpha1-adrenoceptor-mediated nitric oxide production in C6 glioma cells.
  39. Nitric oxide and atrial natriuretic factor stimulate cGMP-dependent membrane insertion of aquaporin 2 in renal epithelial cells.
  40. A colorimetric 96-well microtiter plate assay for the determination of enzymatically formed citrulline.
  41. Stable expression of varied levels of inducible nitric oxide synthase in primary cultures of endothelial cells.
  42. Hepatocyte nuclear factor 1, a transcription factor at the crossroads of glucose homeostasis.
  43. Mechanisms mediating the renal profibrotic actions of vasoactive peptides in transgenic mice.
  44. Modulation of contractions to ergonovine and methylergonovine by nitric oxide and thromboxane A2 in the human coronary artery.
  45. Comparison of endothelium-dependent relaxation in carotid arteries from Japanese white and Watanabe heritable hyperlipidemic rabbits.
  46. Increase in neurogenic nitric oxide metabolism by endothelin-1 in mesenteric arteries from hypertensive rats.
  47. Analyses of the transglutaminase 1 gene mutation and ultrastructural characteristics in a Japanese patient with lamellar ichthyosis.
  48. Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion.
  49. The roles played by crucial free radicals like lipid free radicals, nitric oxide, and enzymes NOS and NADPH in CCl(4)-induced acute liver injury of mice.
  50. Morphine suppresses complement receptor expression, phagocytosis, and respiratory burst in neutrophils by a nitric oxide and mu(3) opiate receptor-dependent mechanism.
  51. Structural preordering in the N-terminal region of ribosomal protein S4 revealed by heteronuclear NMR spectroscopy.
  52. Critical role of a subdomain of the N-terminus of the V1a vasopressin receptor for binding agonists but not antagonists; functional rescue by the oxytocin receptor N-terminus.
  53. Coupling of hydrogen bonding to chromophore conformation and function in photoactive yellow protein.
  54. Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation.
  55. Acceleration of pubertal development following central blockade of the Y1 subtype of neuropeptide Y receptors.
  56. The human T-cell leukemia virus type I (HTLV-I) X region encoded protein p13(II) interacts with cellular proteins.
  57. Nitric oxide inhibits Marek's disease virus replication but is not the single decisive factor in interferon-gamma-mediated viral inhibition.
  58. Nitric oxide mediates 17beta-estradiol-stimulated human and rodent osteoblast proliferation and differentiation.
  59. The homologous pairing domain of RecA also mediates the allosteric regulation of DNA binding and ATP hydrolysis: a remarkable concentration of functional residues.
  60. Lotrafiban: an oral platelet glycoprotein IIb/IIIa blocker.
  61. tRNA aminoacylation by arginyl-tRNA synthetase: induced conformations during substrates binding.
  62. Site-directed mutagenesis of the magB gene affects growth and development in Magnaporthe grisea.
  63. Electrochemical detection of nitroso-arginine as an intermediate between N-hydroxy-arginine and citrulline. An in vitro versus in vivo study using microcarbon electrodes in neuronal nitric oxide synthase and mice brain.
  64. Inducible nitric oxide synthase in the rat testis: evidence for potential roles in both normal function and inflammation-mediated infertility.
  65. Up-regulation of endothelial nitric oxide activity as a central strategy for prevention of ischemic stroke - just say NO to stroke!
  66. Nitric oxide modulates intracellular translocation of pigment organelles in Xenopus laevis melanophores.
  67. Nerve growth factor expression is up-regulated in the rat model of L-arginine-induced acute pancreatitis.
  68. Arginine side-chain dynamics in the HIV-1 rev-RRE complex.
  69. Three-dimensional view of the surface motif associated with the P-loop structure: cis and trans cases of convergent evolution.
  70. Role of neuropeptide Y in the development of two-kidney, one-clip renovascular hypertension in the rat.
  71. A mutation affecting the association equilibrium of formyltransferase from the hyperthermophilic Methanopyrus kandleri and its influence on the enzyme's activity and thermostability.
  72. Efficient protection of human bronchial epithelial cells against sulfur and nitrogen mustard cytotoxicity using drug combinations.
  73. Various nitric oxide donors protect chick embryonic neurons from cyanide-induced apoptosis.
  74. Arginine nutrition and cardiovascular function.
  75. Deoxycorticosterone suppresses the effects of losartan in nitric oxide-deficient hypertensive rats.
  76. Effect of systemic nitric oxide synthase inhibition on postexercise hypotension in humans.
  77. Effect of L-arginine on endothelial injury and hemostasis in rabbit endotoxin shock.
  78. Left ventricular assist device implantation augments nitric oxide dependent control of mitochondrial respiration in failing human hearts.
  79. Interstitial fibrosis of unilateral ureteral obstruction is exacerbated in kidneys of mice lacking the gene for inducible nitric oxide synthase.
  80. Effects of ambient temperature, arginine-to-lysine ratio, and electrolyte balance on performance, carcass, and blood parameters in commercial male turkeys.
  81. Nutritional evaluation of low phytate and high protein corns.
  82. Expression and motor effects of secretin in small and large intestine of the rat.
  83. Nitric oxide production by high molecular weight water-soluble chitosan via nuclear factor-kappaB activation.
  84. Novel S-nitrosothiols do not engender vascular tolerance and remain effective in glyceryltrinitrate-tolerant rat femoral arteries.
  85. Desensitization of sulphonylurea- and nutrient-induced insulin secretion following prolonged treatment with glibenclamide.
  86. L-arginine prevents bone loss and bone collagen breakdown in cyclosporin A-treated rats.
  87. Bradykinin causes endothelium-independent hyperpolarisation and neuromodulation by prostanoid synthesis in hamster mesenteric artery.
  88. Interactions between N-methyl-D-aspartate and nitric oxide in the modulation of ultrasonic vocalizations of infant rats.
  89. Vasodilator-stimulated phosphoprotein serine 239 phosphorylation as a sensitive monitor of defective nitric oxide/cGMP signaling and endothelial dysfunction.
  90. Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids.
  91. Differential transcriptional regulation of rat vasopressin gene expression by estrogen receptor alpha and beta.
  92. The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters.
  93. Synthesis of the marine natural product nalpha-(4-bromopyrrolyl-2-carbonyl)-L-homoarginine, a putative biogenetic precursor of the pyrrole-imidazole alkaloids.
  94. Novel design of nonpeptide AVP V(2) receptor agonists: structural requirements for an agonist having 1-(4-aminobenzoyl)-2,3,4, 5-tetrahydro-1H-1-benzazepine as a template.
  95. Single-amino acid substitutions alter the specificity and affinity of PDZ domains for their ligands.
  96. C4b-binding protein protects coagulation factor Va from inactivation by activated protein C.
  97. Solution structure and activity of the synthetic four-disulfide bond Mediterranean mussel defensin (MGD-1).
  98. Preparation and characterization of acrylic hydrogels neutralized by basic amino acids.
  99. Amino acids and peptides. XXXV. Facile preparation of p-nitroanilide analogs by the solid-phase method.
  100. Highly potent and orally active non-peptide arginine vasopressin antagonists for both V1A and V2 receptors: synthesis and pharmacological properties of 4'-[(4,4-difluoro-5-methylidene-2,3,4,5-tetrahydro-1H-1-benzoazepin-1-y l)carbonyl]-2-phenylbenzanilide derivatives.
  101. 3-(15-Hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen-1-one and its effect on neuropeptide secretion.
  102. Median eminence nitric oxide signaling.
  103. p(1),p(4)-diadenosine 5'-tetraphosphate induces the uptake of arginine and citrulline by a pore on the plasma membrane of bovine aortic endothelial cells.
  104. Differential sensitivity to mutations in a single peptide by two TCRs having identical beta-chains and closely related alpha-chains.
  105. Preparation and characterization of acrylic hydrogels neutralized by basic amino acids.
  106. Amino acids and peptides. XXXV. Facile preparation of p-nitroanilide analogs by the solid-phase method.
  107. Highly potent and orally active non-peptide arginine vasopressin antagonists for both V1A and V2 receptors: synthesis and pharmacological properties of 4'-[(4,4-difluoro-5-methylidene-2,3,4,5-tetrahydro-1H-1-benzoazepin-1-y l)carbonyl]-2-phenylbenzanilide derivatives.
  108. 3-(15-Hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen-1-one and its effect on neuropeptide secretion.
  109. Median eminence nitric oxide signaling.
  110. p(1),p(4)-diadenosine 5'-tetraphosphate induces the uptake of arginine and citrulline by a pore on the plasma membrane of bovine aortic endothelial cells.
  111. Rapid and efficient vascular transport of arginine polymers inhibits myointimal hyperplasia.
  112. The therapeutic efficacy of VP-343, a selective vasopressin V2 receptor antagonist, in the experimental SIADH rat model.
  113. Functional interdependence and colocalization of endothelial nitric oxide synthase and heat shock protein 90 in cerebral arteries.
  114. Hypercholesterolemia inhibits angiogenesis in response to hindlimb ischemia: nitric oxide-dependent mechanism.
  115. Difference in endothelium-derived hyperpolarizing factor-mediated hyperpolarization and nitric oxide release between human internal mammary artery and saphenous vein.
  116. Subpressor dose of L-NAME unmasks hypertensive effect of chronic hyperinsulinemia.
  117. Normal TGF responsiveness during chronic treatment with angiotensin-converting enzyme inhibition: role of AT1 receptors.
  118. S-nitrosothiols cause prolonged, nitric oxide-mediated relaxation in human saphenous vein and internal mammary artery: therapeutic potential in bypass surgery.
  119. Effects of chronic and acute aminoguanidine treatment on tail artery vasomotion in ageing rats.
  120. Role of EDHF in the vasodilatory effect of loop diuretics in guinea-pig mesenteric resistance arteries.
  121. Mechanisms of the cutaneous vasodilator response to local external pressure application in rats: involvement of CGRP, neurokinins, prostaglandins and NO.
  122. Possible involvement of endothelium-derived hyperpolarizing factor (EDHF) in the depressor responses to platelet activating factor (PAF) in rats.
  123. Amlodipine increases nitric oxide synthesis in cytokine-stimulated cultured vascualar smooth muscle cells.
  124. Species-specific TT viruses in humans and nonhuman primates and their phylogenetic relatedness.
  125. Functional analyses and identification of two arginine residues essential to the ATP-utilizing activity of the triple gene block protein 1 of bamboo mosaic potexvirus.
  126. Analysis of conserved basic residues associated with DNA binding (Arg69) and catalysis (Lys76) by the RusA holliday junction resolvase.
  127. A genomics approach to the comprehensive analysis of the glutathione S-transferase gene family in soybean and maize.
  128. Exocytosis requires asymmetry in the central layer of the SNARE complex.
  129. Spontaneous c-Fos rhythm in the rat suprachiasmatic nucleus: location and effect of photoperiod.
  130. Contribution of endogenous nitric oxide to basal vasomotor tone of peripheral vessels and plasma B-type natriuretic peptide levels in patients with congestive heart failure.
  131. The insertion/deletion polymorphism of the angiotensin-converting enzyme gene determines coronary vascular tone and nitric oxide activity.
  132. Reduced procedural risk for coronary catheter interventions in carriers of the coagulation factor VII-Gln353 gene.
  133. Contribution of bradykinin receptor dysfunction to abnormal coronary vasomotion in humans.
  134. Losartan, an angiotensin type 1 receptor antagonist, improves endothelial function in non-insulin-dependent diabetes.
  135. Carbamate kinase can replace in vivo carbamoyl phosphate synthetase. Implications for the evolution of carbamoyl phosphate biosynthesis.
  136. Endothelin-3 regulation of retinal hemodynamics in nondiabetic and diabetic rats.
  137. C-peptide inhibits leukocyte-endothelium interaction in the microcirculation during acute endothelial dysfunction.
  138. Endothelial nitric oxide synthase is a site of superoxide synthesis in endothelial cells treated with glyceryl trinitrate.
  139. An evaluation of potassium ions as endothelium-derived hyperpolarizing factor in porcine coronary arteries.
  140. 5-HT(4) receptors on cholinergic nerves involved in contractility of canine and human large intestine longitudinal muscle.
  141. Antidystonic efficacy of nitric oxide synthase inhibitors in a rodent model of primary paroxysmal dystonia.
  142. Molecular dynamics simulations predict a tilted orientation for the helical region of dynorphin A(1-17) in dimyristoylphosphatidylcholine bilayers.
  143. Expression of aquaporins in the renal connecting tubule.
  144. Hypercapnia induces injury to alveolar epithelial cells via a nitric oxide-dependent pathway.
  145. Vitronectin adsorption to chrysotile asbestos increases fiber phagocytosis and toxicity for mesothelial cells.
  146. Inhibition of K(Ca) channels restores blunted hypoxic pulmonary vasoconstriction in rats with cirrhosis.
  147. Angiotensin IV-mediated pulmonary artery vasorelaxation is due to endothelial intracellular calcium release.
  148. Mesenteric hyporesponsiveness in cirrhotic rats with ascites: role of cGMP and K+ channels.
  149. Vasodilator prostanoids, but not nitric oxide, may account for skeletal muscle hyperaemia in Type I diabetes mellitus.
  150. Evidence for an endothelium-derived hyperpolarizing factor in the superior mesenteric artery from rats with cirrhosis.
  151. Chronic hypoxia increases the NO contribution of acetylcholine vasodilation of the fetal guinea pig heart.
  152. Role of cyclooxygenase-2-derived metabolites and nitric oxide in regulating renal function.
  153. 17beta-estradiol prevents oxidative stress and decreases blood pressure in ovariectomized rats.
  154. Pancreatic nitric oxide and oxygen free radicals in the early stages of streptozotocin-induced diabetes mellitus in the rat.
  155. Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation.
  156. Functional interaction between Ssu72 and the Rpb2 subunit of RNA polymerase II in Saccharomyces cerevisiae.
  157. Nitric oxide and NK(1)-tachykinin receptors in cyclophosphamide-induced cystitis, in rats.
  158. Nitric oxide stimulatory and endothelial protective effects of idoxifene, a selective estrogen receptor modulator, in the splanchnic artery of the ovariectomized rat.
  159. Modulation of nitric-oxide synthase by nicotine.
  160. Tamoxifen acutely relaxes coronary arteries by an endothelium-, nitric oxide-, and estrogen receptor-dependent mechanism.
  161. Mediators of the mitogenic action of human V(1) vascular vasopressin receptors.
  162. NO is involved in MCh-induced accentuated antagonism via type II PDE in the canine blood-perfused SA node.
  163. Biphasic response of cardiac NO synthase isoforms to ischemic preconditioning in conscious rabbits.
  164. Advanced glycation endproduct-modified superoxide dismutase-1 (SOD1)-positive inclusions are common to familial amyotrophic lateral sclerosis patients with SOD1 gene mutations and transgenic mice expressing human SOD1 with a G85R mutation.
  165. Steady state is not achieved for most plasma amino acids during 12 hours of fasting in the neonatal piglet.
  166. Growth hormone stimulation testing in both short and normal statured children: use of an immunofunctional assay.
  167. p53 codon 72 polymorphism in vulval cancer and vulval intraepithelial neoplasia.
  168. Role of nitric oxide and superoxide in acute cardiac allograft rejection in rats.
  169. Renal expression of constitutive NOS and DDAH: separate effects of salt intake and angiotensin.
  170. Autocrine effects of nitric oxide on HCO(3)(-) transport by rat thick ascending limb.
  171. Hyaluronan content in the kidney in different states of body hydration.
  172. Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines.
  173. Cysteine residues in the C-terminus of the neutral- and basic-amino-acid transporter heavy-chain subunit contribute to functional properties of the system b(0,+)-type amino acid transporter.
  174. Stichopus japonicus arginine kinase: gene structure and unique substrate recognition system.
  175. The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes.
  176. Complex stenosis morphology and vasomotor responses to inhibition of nitric oxide synthesis.
  177. Interdependence of adenosine and nitric oxide in hepato-splanchnic circulation during sepsis.
  178. Assay of diverse protease activities on the basis of a small synthetic substrate.
  179. Prolonged exposure to hyperbaric oxygen induces neuronal damage in primary rat cortical cultures.
  180. Nitric oxide mediates laminin-induced neurite outgrowth in PC12 cells.
  181. Role of catalase in Campylobacter jejuni intracellular survival.
  182. Augmentation of nitric oxide production by gamma interferon in a mouse vascular endothelial cell line and its modulation by tumor necrosis factor alpha and lipopolysaccharide.
  183. Prolonged exposure to hyperbaric oxygen induces neuronal damage in primary rat cortical cultures.
  184. Nitric oxide mediates laminin-induced neurite outgrowth in PC12 cells.
  185. Role of catalase in Campylobacter jejuni intracellular survival.
  186. Augmentation of nitric oxide production by gamma interferon in a mouse vascular endothelial cell line and its modulation by tumor necrosis factor alpha and lipopolysaccharide.
  187. NO contributes to proliferative suppression in a murine model of filariasis.
  188. The role of reactive nitrogen species in secondary spinal cord injury: formation of nitric oxide, peroxynitrite, and nitrated protein.
  189. Messenger RNAs located in myelin sheath assembly sites.
  190. Role of tumor necrosis factor-alpha in neuronal and glial apoptosis after spinal cord injury.
  191. Swarming of Pseudomonas aeruginosa is dependent on cell-to-cell signaling and requires flagella and pili.
  192. Two-dimensional gel electrophoresis analyses of pH-dependent protein expression in facultatively alkaliphilic Bacillus pseudofirmus OF4 lead to characterization of an S-layer protein with a role in alkaliphily.
  193. Calcium regulates estrogen increase in permeability of cultured CaSki epithelium by eNOS-dependent mechanism.
  194. Hyposmolality stimulates Na(+)/H(+) exchange and HCO(3)(-) absorption in thick ascending limb via PI 3-kinase.
  195. Voltage dependence of L-arginine transport by hCAT-2A and hCAT-2B expressed in oocytes from Xenopus laevis.
  196. Cerebral nitric oxide concentration and microcirculation during hypercapnia, hypoxia, and high intracranial pressure in pigs.